The Biological Chemistry of Magnesium

Jacket Description/Back: The Biological Chemistry of Magnesium Edited by J. A. Cowan Recent years have witnessed a revolution in the understanding of magnesium biochemistry, especially the pivotal role of magnesium ion in nucleic acid biochemistry. This graduate text presents a unique and comprehensive review of all major areas of current research interest, from inorganic chemistry, nucleic acid biochemistry, and enzymology through ribozyme activation, drug-magnesium-DNA interactions, and magnesium transport by selective membrane channels. Introductory chapters provide a useful review for the non-specialist, including descriptions of essential solution chemistry and physical methods for monitoring magnesium biochemistry. Its readable style and emphasis on understanding at the molecular level makes The Biological Chemistry of Magnesium accessible and relevant to researchers and graduate students in the field, as well as non-specialists in biochemistry, molecular biology, biotechnology, bioinorganic chemistry, and pharmaceutical sciences. Also available from VCH: Inorganic Biochemistry: An Introduction J. A. Cowan Hardcover (ISBN 1-56081-537-X) Manganese Redox Enzymes V. L. Pecoraro, ed. Hardcover (ISBN 0-89573-729-9) The Bioinorganic Chemistry of Nickel J. R. Lancaster, Jr. Hardcover (ISBN 0-89573-338-2) Table of Contents: From the Contents: Introduction to the Biological Chemistry of Magnesium Ion/ Physical Methods to study the Biological Chemistry of Magnesium/ Metal Substitution as a Probe of the Biological Chemistry of Magnesium Ion/ Modes and Dynamics of Mg 2+-Polynucleotide Interactions/ Magnesium as the Catalytic Center of RNA Enzymes/ Magnesium-Dependent Enzymes in Nucleic Acid Biochemistry/ Magnesium-Dependent Enzymes in General Metabolism/ Biological Chemistry of Magnesium Ion with Physiological Metabolites, Nucleic Acids and Drug Molecules/ Genetics and Molecular Biology of Magnesium Transport Systems/ Regulation of Cytosolic Magnesium Ion in Hearts